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What Is It
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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Overdosage
Fast heartbeat; hallucinations (seeing, hearing, or feeling things that are not there); loss of consciousness ; nausea; seizures (convulsions) ; vomiting
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Significant Interactions:
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Tricyclic antidepressants (amitriptyline [e.g., Elavil
], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g.,
Vivactil], trimipramine [e.g., Surmontil]) or
-
- Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegi
line [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X Do not take Zyban while you are taking or within 14 days of taking an MAO inhibitor
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Special warnings about this medication
Drinking of alcoholic beverages should be limited or avoided, if possible, while taking Zyban. This will help prevent seizures.
This medicine may cause some people to feel a false sense of we
ll-being, or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerou
s if you are dizzy or are not alert and clearheaded.
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Proper Use of This Medicine
Zyban comes as a tablet to take by mouth. It is usually taken one to three times a day and may be taken with or without food. Do not crush, chew, or divide Wellbutrin SR or Zyban tablets. Follow the d
irections on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Zyban exactly as directed.
Continue to take Zyban even if you
feel well. Do not stop taking Zyban without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug
must be taken regularly for a few weeks before its full effect is felt.
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Possible Side Effect
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyban.
<
br> The most common side effects are:
Dry mouth and sleeplessness
These are generally mild and usually disappear after a few weeks. If you have difficulty sleeping, avoid taking Zyban close t
o bedtime and ask your doctor about reducing your dosage.
More common side effects may include:
Abdominal pain, abnormal dreams, anxiety, constipation, diarrhea, disturbed concentration
, dizziness, joint pain, increased cough, itching, nasal inflammation, nausea, nervousness, rash, sore throat
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To Continue
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